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Index > Protein center > SLC18A2(Gene name) > Human
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  • SLC18A2 (Gene name),
  • Synaptic vesicular amine transporter (Protein name ),  VMAT2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC18A2(SVMT;VMAT2);
    Protein name:
    Synaptic vesicular amine transporter;
    Alternative:
    Solute carrier family 18 member 2;Monoamine transporter;Vesicular amine transporter 2(VAT2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SLC6A3.
    Function:
    Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.
    Subcellular Location:
    Cytoplasmic vesicle membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    514
    Sequence:
    50:
    MALSELALVR | WLQESRRSRK | LILFIVFLAL | LLDNMLLTVV | VPIIPSYLYS | 
    100:
    IKHEKNATEI | QTARPVHTAS | ISDSFQSIFS | YYDNSTMVTG | NATRDLTLHQ | 
    150:
    TATQHMVTNA | SAVPSDCPSE | DKDLLNENVQ | VGLLFASKAT | VQLITNPFIG | 
    200:
    LLTNRIGYPI | PIFAGFCIMF | VSTIMFAFSS | SYAFLLIARS | LQGIGSSCSS | 
    250:
    VAGMGMLASV | YTDDEERGNV | MGIALGGLAM | GVLVGPPFGS | VLYEFVGKTA | 
    300:
    PFLVLAALVL | LDGAIQLFVL | QPSRVQPESQ | KGTPLTTLLK | DPYILIAAGS | 
    350:
    ICFANMGIAM | LEPALPIWMM | ETMCSRKWQL | GVAFLPASIS | YLIGTNIFGI | 
    400:
    LAHKMGRWLC | ALLGMIIVGV | SILCIPFAKN | IYGLIAPNFG | VGFAIGMVDS | 
    450:
    SMMPIMGYLV | DLRHVSVYGS | VYAIADVAFC | MGYAIGPSAG | GAIAKAIGFP | 
    500:
    WLMTIIGIID | ILFAPLCFFL | RSPPAKEEKM | AILMDHNCPI | KTKMYTQNNI | 
    514:
    QSYPIGEDEE | SESD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    MIM:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Synaptic vesicular amine transporter
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    E10969m
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    ELISA Kit for Human Synaptic vesicular amine transporter
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    E10969b
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    ELISA Kit for Human Synaptic vesicular amine transporter
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    E10969h
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    96T
    ELISA Kit for Human Synaptic vesicular amine transporter
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    E10969r
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    Packing:
    96T
    CLIA Kit for Human Synaptic vesicular amine transporter
    Cat.:
    U10969r
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    Packing:
    96T
    CLIA Kit for Human Synaptic vesicular amine transporter
    Cat.:
    U10969h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Synaptic vesicular amine transporter
    Cat.:
    U10969b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Synaptic vesicular amine transporter
    Cat.:
    U10969m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Synaptic vesicular amine transporter
    Cat.:
    P10969Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Synaptic vesicular amine transporter
    Cat.:
    P10969Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Synaptic vesicular amine transporter
    Polyclonal Antibody for Human Synaptic vesicular amine transporter
    Cat.:
    P10969Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Synaptic vesicular amine transporter
    Monoclonal Antibody for Human Synaptic vesicular amine transporter
    Monoclonal Antibody for Human Synaptic vesicular amine transporter
    Monoclonal Antibody for Human Synaptic vesicular amine transporter
    Protein for Human Synaptic vesicular amine transporter
    Protein for Human Synaptic vesicular amine transporter
    Protein for Human Synaptic vesicular amine transporter
    Protein for Human Synaptic vesicular amine transporter

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    Recovery
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    Linearity
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    References
    1. 1.
      "A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs."
      Surratt C.K. , Persico A.M. , Yang X.D. , Edgar S.R. , Bird G.S. , Hawkins A.L. , Griffin C.A. , Li X. , Jabs E.W. , Uhl G.R.
      FEBS Lett.318:325-330(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Functional identification and molecular cloning of a human brain vesicle monoamine transporter."
      Erickson J.D. , Eiden L.E.
      J. Neurochem.61:2314-2317(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Chromosomal localization of the human vesicular amine transporter genes."
      Peter D. , Finn J.P. , Klisak I. , Liu Y. , Kojis T. , Heinzmann C. , Roghani A. , Sparkes R.S. , Edwards R.H.
      Genomics18:720-723(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Substantia nigra.
    4. 4.
      "Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+."
      Lesch K.P. , Gross J. , Wolozin B.L. , Murphy D.L. , Riederer P.
      J. Neural Transm.93:75-82(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene."
      Kunugi H. , Ishida S. , Akahane A. , Nanko S.
      Mol. Psychiatry6:456-460(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Uterus.
    7. 7.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    10. 10.
      "Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond."
      Thiriot D.S. , Sievert M.K. , Ruoho A.E.
      Biochemistry41:6346-6353(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BOND
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
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